Validity of eosinophil count and monocyte-lymphocyte ratio for early detection of neonatal sepsis

Background: Sepsis is a major cause of mortality in neonatal. Diagnosing neonatal sepsis challenge, as its clinical symptoms are not specific. Various studies have been conducted to identify infection markers for early identification sepsis, but none shown satisfactory results. Therefore, we aimed determine the validity eosinophil count and monocyte lymphocyte ratio (MLR) detection sepsis. Objective: To Methods: This study was retrospective with diagnostic test. Data were collected from medical records neonates early-onset (EONS) or clinically EONS who admitted Neonatal Ward Sanglah Hospital between April 2020 December 2020. The ROC curve used cut-off point MLR. Furthermore, chi-squared test sensitivity, specificity, PPV, NPV Results: total sample 100 subjects, 28 subjects had positive blood culture (28%). (cut-off 0.16x103/µL 160 cell/mm3) produced sensitivity 57.14%, specificity 65.28%, PPV 39.02%, 79.66%. At value 0.38, MLR 67.86%, 72.22%, 48.72%, 85.25%. Conclusion: Children obesity found be significantly related elevated pressure (hypertension).